A comprehensive review of the available scientific evidence has revealed nomagnesium citrate ebay indication that isoflavones at levels typically found in food supplements cause harm to post-menopausal women.###Isoflavones are naturally occurring substances which are found, among other sources, in soy, red clover and kudzu root.###Their extracts are often used as ingredients in nutritional supplements.###“The evidence reviewed does not suggest there are harmful effects on the three organs considered for this assessment – mammary gland, uterus and thyroid gland,” says Dr Alicja Mortensen, chair of the European Food Safety Authority (EFSA) expert Panel on Food Additives (ANS), which carried out the assessment.###“We considered studies testing doses of isoflavones that are typically found in food supplements targeted at menopausal women in the European Union.”###“These conclusions were drawn on the basis of data collected on post-menopausal women and are supported by the results from animal studies,” she adds.###“These are limited to the doses and duration of intakes investigated in these studies that range from three months to just under a year for those products available on the market in Europe.&#citracal plus with magnesium8221;###EFSA’s experts also attempted to assess the possible risks for women during the transition period to menopause and for menopausal women with a history or family history of cancer.###They found, however, that there is no data to assess the safety of these substances for these groups of women.###In line with EFSA’s new ‘Promoting Methods for Evidence Use’ approach, the ANS Panel captured the strategy for performing this risk assessment in a protocol that documents all the steps taken in reaching its final conclusions. T###This was the first EFSA opinion to pilot this new way of working, which enhances the robustness and transparency of the scientific process.###“Defining a protocol before the start of the assessment helped us a lot to clarify the scope of our review and the information needs upfront,” says Prof Ursula Gundert-Remy, an ANS Panel Member and chair of the Panel’s working group on isoflavones.###“The focus was exclusively on the possible healthcalcium citrate v carbonate effects on the uterus, thyroid gland and mammary gland specifically in peri- and post-menopausal women.&liposomal ferric pyrophosphate#8221;###“For example, this made it clear that we would exclude all studies on men or data related to the use of soy formula in infants,” she says.###“It was also clear that information about the possible benefits of isoflavone-based food supplements was outside the scope ofmagnesium citrate for pregnancy this assessment.”